Technology

How DIOS reads your body clock.

TipTraQ clinical monitoring, blood panels, then smartphone sensors — one MLux phase reading.

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The gold standard

MLux phase time is the most accurate measure of your body clock.

  • Melanopic Lux phase time (MLux) is the moment melatonin begins rising in the evening — the most reliable circadian biomarker in clinical research.
  • Traditional MLux phase time requires hourly saliva samples under dim light over 6-8 hours. Clinically impractical at scale.
  • DIOS derives a MLux phase time passively — from sleep architecture, autonomic data, and smartphone sensors. No saliva sample required.
  • Every personalised output in DIOS — medication windows, supplement timing, zeitgeber cues — is driven by MLux phase time.

The DIOS method

Clinical grade first — three layers, one body clock reading.

Layer 1 TipTraQ

FDA 510(k)-cleared clinical-grade home monitoring. Sleep onset, REM latency, ANS balance, AHI, SpO₂. Confidence: 38% night one to 94% night seven.

Layer 2 Bloods

Gominak panel — D3, B12, ferritin, B5. Metabolic substrate of the circadian system. D3 target: 150-200 nmol/L. Confidence: up to 75%.

Layer 3 Smartphone

Sleep timing. Morning light. Solar zenith for VDR activation. Fitzpatrick skin calibration. Confidence: up to 60%.

The calculation

How MLux phase time is calculated.

  1. 1.Sleep onset anchor: MLux phase time typically occurs 2 hours before sleep onset.
  2. 2.REM latency correction: Delayed REM beyond 85 minutes shifts MLux phase time estimate later by 0.25 minutes per minute of delay.
  3. 3.ANS correction: Low parasympathetic activity at sleep onset indicates melatonin has not fully risen.
  4. 4.AHI modifier: Apnea events above AHI 15 reduce confidence score — sympathetic activation suppresses the PNS signal.
  5. 5.Rolling average: Each additional night narrows the confidence band.

Confidence builds nightly

More nights. More precision.

Night 1

38%

±75 min

Starting estimate

Night 2

65%

±45 min

Direction confirmed

Night 3

84%

±20 min

Clinically actionable

Night 7

94%

±12 min

Sleep lab equivalent

The VDR connection

Vitamin D is not just for bones.

  • VDR response elements are present on CLOCK and BMAL1 genes — the master regulators of circadian rhythm.
  • Low D3 below 150 nmol/L dampens circadian amplitude, fragments sleep, and reduces medication efficacy.
  • The Gominak protocol targets D3 at 150-200 nmol/L. The Coimbra protocol uses supervised high-dose D3 at 200-400 nmol/L for autoimmune conditions.

The medication evidence

Eight medications. Published timing evidence.

Atorvastatin

Standard: Take at night

DIOS: 3h after MLux phase

Ramipril

Standard: Take in morning

DIOS: 1h after MLux phase

Amlodipine

Standard: Take at night

DIOS: 2h after MLux phase

Sertraline

Standard: Take in morning

DIOS: 6h after MLux phase

Metformin

Standard: Take with meals

DIOS: First meal post-MLux phase +9h

Prednisolone

Standard: Take in morning

DIOS: 6h after MLux phase

Salmeterol

Standard: Take at night

DIOS: 4h after MLux phase

Levothyroxine

Standard: Take in morning fasting

DIOS: 5h after MLux phase

References

Key peer-reviewed sources.

  • Smolensky MH, Peppas NA. Chronobiology, drug delivery, and chronotherapeutics. Advanced Drug Delivery Reviews 2007.
  • Gominak SC, Stumpf WE. The world epidemic of sleep disorders is linked to vitamin D deficiency. Medical Hypotheses 2012.
  • Coimbra JG et al. High-dose vitamin D3 in autoimmune disease. CNS Drugs 2014.
  • Huang W et al. Circadian clock-controlled hematopoiesis. Frontiers in Immunology 2021.
  • Burgess HJ et al. Sleep and circadian influences on the human immune response. Chronobiology International 2019.
  • Archer SN et al. Per3 polymorphism linked to delayed sleep phase syndrome. Sleep 2003.
  • Kim JK et al. Wearable technology and systems modeling for personalized chronotherapy. Current Opinion in Systems Biology 2020.